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Aging has the opposite effect on cAMP and cGMP circadian variations in rat Leydig cells.
Baburski AZ, Sokanovic SJ, Andric SA, Kostic TS. Baburski AZ, et al. J Comp Physiol B. 2017 May;187(4):613-623. doi: 10.1007/s00360-016-1052-7. Epub 2016 Dec 3. J Comp Physiol B. 2017. PMID: 27915366
Reduced amplitude of cAMP circadian oscillation was probably associated with changed expression of genes involved in cAMP production (increased circadian pattern of Adcy7, Adcy9, Adcy10 and decreased Adcy3); cAMP degradation (increased Pde4a, decreased Pde8b, canceled rhyt …
Reduced amplitude of cAMP circadian oscillation was probably associated with changed expression of genes involved in cAMP production (increa …
Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells.
Stojkov NJ, Janjic MM, Bjelic MM, Mihajlovic AI, Kostic TS, Andric SA. Stojkov NJ, et al. Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1239-51. doi: 10.1152/ajpendo.00554.2011. Epub 2012 Feb 28. Am J Physiol Endocrinol Metab. 2012. PMID: 22374756 Free article.
In addition to acute IMO effects, repeated IMO increased transcription of Star (steroidogenic acute regulatory protein) and Arr19 (androgen receptor corepressor 19 kDa) in Leydig cells. In the same cells, the transcription of adenylyl cyclases (Adcy7, Adcy9, Adcy10) and cA …
In addition to acute IMO effects, repeated IMO increased transcription of Star (steroidogenic acute regulatory protein) and Arr19 (androgen …